1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

Base Information

Chemical Name:1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one
CAS No.:1429192-72-2
Molecular Formula:C₂₃H₁₉N₃OS₂
Molecular Weight:417.555
Hs Code.:

Synonyms:1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

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Chemical Property of 1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

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Technology Process of 1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

There total 6 articles about 1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1429192-14-2
2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

: 74-88-4
methyl iodide

: 1429192-72-2
1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: 2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm4002346

Reference yield: 83.0%

: 1429192-72-2
1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 71.0%

: 499770-66-0
5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-carboxaldehyde

: 4424-17-3
2-aminobenzanilide

: 74-88-4
methyl iodide

: 1429192-72-2
1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: 5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-carboxaldehyde; 2-aminobenzanilide; In methanol; at 20 ℃;

methyl iodide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;