4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Base Information

Chemical Name:4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate
CAS No.:1472067-98-3
Molecular Formula:C₁₆H₁₃F₂N₅O₅S
Molecular Weight:425.373
Hs Code.:

Synonyms:4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

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Chemical Property of 4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

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Technology Process of 4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

There total 7 articles about 4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1472068-47-5
4-{[(2,2-difluorobenzo[1,3]dioxol-5-yl)-[1,2,4]triazol-4-ylamino]-methyl}phenol

: 1472067-98-3
4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;
DOI:10.1002/cmdc.201300015

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1472067-98-3
4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / ethanol / 1 h / Reflux

2.1: sodium tetrahydroborate; ethanol / 18 h / 0 - 20 °C

3.1: sodium nitrite; sulfuric acid / chloroform; water / 1 h / 0 °C

3.2: 20 °C

4.1: pyridine / 2 h / Reflux

5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C

6.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With pyridine; sodium tetrahydroborate; ethanol; sulfuric acid; palladium 10% on activated carbon; sulphamoyl chloride; hydrogen; toluene-4-sulfonic acid; sodium nitrite; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl acetamide; water;
DOI:10.1002/cmdc.201300015

Reference yield:

: 1544-85-0
2,2-difluoro-benzo[1,3]dioxol-5-ylamine

: 1472067-98-3
4-{[(2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / ethanol / 1 h / Reflux

2.1: sodium tetrahydroborate; ethanol / 18 h / 0 - 20 °C

3.1: sodium nitrite; sulfuric acid / chloroform; water / 1 h / 0 °C

3.2: 20 °C

4.1: pyridine / 2 h / Reflux

5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C

6.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With pyridine; sodium tetrahydroborate; ethanol; sulfuric acid; palladium 10% on activated carbon; sulphamoyl chloride; hydrogen; toluene-4-sulfonic acid; sodium nitrite; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl acetamide; water;
DOI:10.1002/cmdc.201300015