ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate

Base Information

• Chemical Name: ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate
• CAS No.: 1314094-26-2
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364

Synonyms:ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate

Chemical Property of ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate

Chemical Property:

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Technology Process of ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate

There total 1 articles about ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 1-benzyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate (1011240-58-6) + formic acid ethyl ester (109-94-4) → ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate (1314094-26-2)

Guidance literature:

ethyl 1-benzyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate; With potassium tert-butylate; In toluene; at 0 ℃; for 3h; Inert atmosphere;

formic acid ethyl ester; In toluene; at 0 ℃; Inert atmosphere;

DOI:10.1002/cmdc.201100085

Reference yield: 60.0%

ethyl 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one-2-carboxylate (1314094-26-2) + urea (57-13-6) → ethyl 9-benzyl-3,5,6,9-tetrahydro-2H-pyrrolo[3,2-h]quinazoline-2-one-8-carboxylate (1314093-92-9)

Guidance literature:

In ethanol; for 24h; Inert atmosphere; Reflux;

DOI:10.1002/cmdc.201100085

upstream raw materials:

ethyl 1-benzyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

formic acid ethyl ester

Downstream raw materials:

ethyl 9-benzyl-3,5,6,9-tetrahydro-2H-pyrrolo[3,2-h]quinazoline-2-one-8-carboxylate

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