1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Base Information

Chemical Name:1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene
CAS No.:1453393-84-4
Molecular Formula:C₂₀H₂₆F₄N₂O₇
Molecular Weight:482.429
Hs Code.:

Synonyms:1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

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Chemical Property of 1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

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Technology Process of 1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

There total 3 articles about 1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1453393-36-6
5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)aniline

: 1453393-84-4
1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1039/c3md00110e

Reference yield:

: 400-70-4
2,4-dichloro-5-nitrobenzotrifluoride

: 1453393-84-4
1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / 1,4-dioxane / 144 h / 100 °C / Sealed tube

2: potassium carbonate / dimethyl sulfoxide / 72 h / 90 °C

3: triethylamine; dmap / dichloromethane / 18 h / 20 °C

With dmap; ammonia; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c3md00110e

Reference yield:

: 35375-74-7
5-chloro-2-nitro-4-(trifluoromethyl)aniline

: 1453393-84-4
1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 72 h / 90 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c3md00110e