(1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

Base Information

Chemical Name:(1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol
CAS No.:1428228-23-2
Molecular Formula:C₂₇H₄₅NO₂
Molecular Weight:415.66
Hs Code.:

Synonyms:(1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

Suppliers and Price of (1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

There total 8 articles about (1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1428228-08-3
(1R,3aR,4R,5S,7aR)-5-amino-1-((R)-1,5-dimethylhexyl)-3a,7a-dimethyloctahydroinden-4-ol

: 123-11-5
4-methoxy-benzaldehyde

: 1428228-23-2
(1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.01.041

Reference yield:

: 1428228-07-2
(1R,3aR,5S,7aR)-5-azido-1-((R)-1,5-dimethylhexyl)-3a,7a-dimethyloctahydroinden-4-one

: 1428228-23-2
(1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: sodium cyanoborohydride; acetic acid / methanol / 12 h / 40 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2013.01.041

Reference yield:

: 66251-18-1
Grundmann's ketone

: 1428228-23-2
(1R,3aR,4R,5S,7aR)-1-((R)-1,5-dimethylhexyl)-5-(4-methoxybenzylamino)-3a,7a-dimethyloctahydroinden-4-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; lithium iodide / dichloromethane / 24 h / 20 °C / Inert atmosphere; Darkness

2.1: diethylzinc / diethyl ether / 18 h / Inert atmosphere; Reflux

3.1: water; sodium hydroxide / ethanol / 12 h / Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide; sodium acetate / tetrahydrofuran; water / 12 h / 20 °C

6.1: sodium hydrogencarbonate; sodium azide / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

8.1: sodium cyanoborohydride; acetic acid / methanol / 12 h / 40 °C / Inert atmosphere

With N-Bromosuccinimide; lithium aluminium tetrahydride; sodium azide; water; diethylzinc; sodium acetate; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; lithium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; 2.1: |Simmons-Smith Cyclopropanation;
DOI:10.1016/j.bmc.2013.01.041