ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate

Base Information

Chemical Name:ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate
CAS No.:1428548-26-8
Molecular Formula:C₂₄H₂₀N₄O₅
Molecular Weight:444.447
Hs Code.:

Synonyms:ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate

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Chemical Property of ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate

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Technology Process of ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate

There total 7 articles about ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: N-(diphenylmethyl)-4-hydroxy-2-[(hydroxyimino)methyl]pyrimidine-5-carboxamide

: 623-47-2
propynoic acid ethyl ester

: 1428548-26-8
ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate

Guidance literature:: N-(diphenylmethyl)-4-hydroxy-2-[(hydroxyimino)methyl]pyrimidine-5-carboxamide; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 1h;

propynoic acid ethyl ester; With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 20.0%

: 1428548-46-2
(E)-N-(diphenylmethyl)-4-hydroxy-2-[(E)-(hydroxyimino)methyl]pyrimidine-5-carboxamide

: 623-47-2
propynoic acid ethyl ester

: 1428548-26-8
ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate

Guidance literature:: (E)-N-(diphenylmethyl)-4-hydroxy-2-[(E)-(hydroxyimino)methyl]pyrimidine-5-carboxamide; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 1h;

propynoic acid ethyl ester; With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1428548-40-6
ethyl 2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylate

: 1428548-26-8
ethyl 3-{5-[(diphenylmethyl)carbamoyl]-4-hydroxypyrimidin-2-yl}isoxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; potassium hydroxide / 1 h / 70 °C

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

3.1: palladium on activated charcoal; ammonium formate / methanol / Reflux

4.1: Dess-Martin periodane / dichloromethane / 20 °C

5.1: hydroxylamine hydrochloride; sodium acetate / water / 3 h / 100 °C

6.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 60 °C

6.2: 0 - 20 °C

With N-chloro-succinimide; palladium on activated charcoal; hydroxylamine hydrochloride; water; ammonium formate; sodium acetate; Dess-Martin periodane; triethylamine; HATU; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;