butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

Base Information

Chemical Name:butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate
CAS No.:1300746-14-8
Molecular Formula:C₂₄H₂₅ClN₄O₃
Molecular Weight:452.941
Hs Code.:

Synonyms:butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

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Chemical Property of butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

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Technology Process of butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

There total 13 articles about butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1300019-38-8
[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

: 71-36-3
butan-1-ol

: 1300746-14-8
butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

Guidance literature:: [(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

butan-1-ol; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm401088k

Reference yield:

: 1300019-48-0
methyl N¹-[2-[(4-chlorophenyl)carbonyl]-4-(methyloxy)phenyl]-N²-{[(9H-fluoren-9-ylmethyl)oxy]carbonyl}-L-α-asparaginate

: 1300746-14-8
butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 24 h / Reflux

1.2: 2 h / 60 °C

2.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

3.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

3.2: 1 h / 20 °C

4.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

5.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

6.1: dmap; diisopropyl-carbodiimide / 48 h / 20 °C

With dmap; tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1300019-46-8
(S)-methyl 2-(5-(4-chlorophenyl)-7-methoxy-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate

: 1300746-14-8
butyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f ][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

2.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

2.2: 1 h / 20 °C

3.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

5.1: dmap; diisopropyl-carbodiimide / 48 h / 20 °C

With dmap; tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; 1,2-dichloro-ethane;