[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

Base Information

Chemical Name:[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid
CAS No.:1300019-38-8
Molecular Formula:C₂₀H₁₇ClN₄O₃
Molecular Weight:396.833
Hs Code.:

Synonyms:[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

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Chemical Property of [(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of [(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

There total 14 articles about [(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1300019-40-2
methyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzol[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

: 1300019-38-8
[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

Guidance literature:: methyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzol[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

With hydrogenchloride; In water;

Reference yield:

: 91713-54-1
[2-amino-5-(methyloxy)phenyl](4-chlorophenyl)methanone

: 1300019-38-8
[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloroform / 1 h / 60 °C

2.1: triethylamine / dichloromethane / 24 h / Reflux

2.2: 2 h / 60 °C

3.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

4.1: hydrazine hydrate / tetrahydrofuran / 5 h / 0 - 15 °C

5.1: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C

6.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; 1,2-dichloro-ethane;

Reference yield:

: 1300019-48-0
methyl N¹-[2-[(4-chlorophenyl)carbonyl]-4-(methyloxy)phenyl]-N²-{[(9H-fluoren-9-ylmethyl)oxy]carbonyl}-L-α-asparaginate

: 1300019-38-8
[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 24 h / Reflux

1.2: 2 h / 60 °C

2.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

3.1: hydrazine hydrate / tetrahydrofuran / 5 h / 0 - 15 °C

4.1: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C

5.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;