1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one

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Chemical Name:1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one
CAS No.:1429047-09-5
Molecular Formula:C₁₆H₁₆N₄O₅
Molecular Weight:344.327
Hs Code.:

Synonyms:1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one

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Chemical Property of 1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one

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Technology Process of 1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one

There total 4 articles about 1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1429047-05-1
2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

: 1429047-09-5
1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2013.03.005

Reference yield:

: 914801-62-0
2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate

: 1429047-09-5
1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 80 °C

2: sodium hydroxide / methanol / 2 h / 20 °C

With toluene-4-sulfonic acid; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.03.005

Reference yield:

: 122336-54-3
2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate

: 1429047-09-5
1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / acetic acid; tetrahydrofuran / 7 h / 20 °C

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 80 °C

3: sodium hydroxide / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.03.005