2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

Base Information

• Chemical Name: 2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate
• CAS No.: 1429047-05-1
• Molecular Formula: C₃₇H₂₈N₄O₈
• Molecular Weight: 656.651
• Mol file: 1429047-05-1.mol

Synonyms:2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

Chemical Property of 2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate

There total 2 articles about 2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate (914801-62-0) + benzaldehyde (100-52-7) → 2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate (1429047-05-1)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1016/j.tet.2013.03.005

Reference yield:

2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate (122336-54-3) → 2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate (1429047-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / acetic acid; tetrahydrofuran / 7 h / 20 °C

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 80 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2013.03.005

Reference yield: 60.0%

2-(benzoyloxymethyl)-5-(2-oxo-8-phenyl-2,9-dihydro-1H-purin-1-yl)tetrahydrofuran-3,4-diyl dibenzoate (1429047-05-1) → 1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one (1429047-09-5)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2013.03.005

upstream raw materials:

2-(4-amino-5-nitro-2-oxopyrimidin-1(2H)-yl)-5((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate

2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate

benzaldehyde

Downstream raw materials:

1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-phenyl-1H-purin-2(9H)-one