2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester

Base Information

Chemical Name:2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester
CAS No.:283614-74-4
Molecular Formula:C₂₁H₂₀Br₂O₇
Molecular Weight:544.194
Hs Code.:

Synonyms:2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester

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Chemical Property of 2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester

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Technology Process of 2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester

There total 4 articles about 2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: tributyl-(4-methoxymethoxyphenyl)-stannane

: 2-(3,5-dibromo-4-methoxy-phenyl)-3-(trifluoromethanesulfonyloxy)-but-2-enedioic acid dimethyl ester

: 283614-74-4
2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester

Guidance literature:: With triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 70 - 75 ℃; for 1h;
DOI:10.1016/S0040-4020(00)00168-X

Reference yield:

: 23786-14-3
4-methoxy-phenyl acetic acid methyl ester

: 283614-74-4
2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Br₂; FeBr₂ / CHCl₃ / 96 h / 20 °C

2: 100 percent / NaOMe / methanol / 5 h / Heating

3: 84 percent / iPr₂NEt / CH₂Cl₂ / 0 - 20 °C

4: 81 percent / Ph₃P / tris(dibenzylideneacetone)dipalladium / dimethylformamide / 1 h / 70 - 75 °C

With bromine; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; iron(II) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 1: Bromination / 2: Condensation / 3: Substitution / 4: coupling;
DOI:10.1016/S0040-4020(00)00168-X

Reference yield:

: 212688-03-4
3,5-dibromo-4-methoxy-phenyl acetic acid methyl ester

: 283614-74-4
2-(3,5-dibromo-4-methoxy-phenyl)-3-(4-methoxymethoxy-phenyl)-but-2-enedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaOMe / methanol / 5 h / Heating

2: 84 percent / iPr₂NEt / CH₂Cl₂ / 0 - 20 °C

3: 81 percent / Ph₃P / tris(dibenzylideneacetone)dipalladium / dimethylformamide / 1 h / 70 - 75 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Substitution / 3: coupling;
DOI:10.1016/S0040-4020(00)00168-X