1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:221526-50-7
Molecular Formula:C₂₂H₃₀N₂O₆S
Molecular Weight:450.556
Hs Code.:

Synonyms:1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

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Chemical Property of 1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

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Technology Process of 1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

There total 10 articles about 1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 593288-88-1
1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

: 221526-50-7
1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: 1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate; With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 20 ℃; for 1h;

In benzene; for 0.5h; Heating;

Reference yield:

: 221526-48-3
4-(1-benzenesulfonyl-2-oxo-piperidin-3-ylidenemethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 221526-50-7
1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / H₂ / Pd-C / ethyl acetate / 48 h / 20 °C

2.1: 70 percent / LiN(TMS)2 / tetrahydrofuran / 2 h / -78 °C

3.1: m-CPBA; NaHCO₃ / H₂O; CH₂Cl₂ / 1 h / 20 °C

3.2: 87 percent / benzene / 0.5 h / Heating

With hydrogen; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

: 221526-47-2
1,1-dimethylethyl (4S)-4-[(RS)-[(3RS)-3-benzenesulfonyl-2-oxopiperidin-3-yl]hydroxymethyl]-2,2-dimethyloxazolidine-3-carboxylate

: 221526-50-7
1,1-dimethylethyl (4R)-4-[1-benzenesulfonyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: MsCl; Et₃N / CH₂Cl₂ / 3.5 h / 0 - 20 °C

1.2: 71 percent / DBU / CH₂Cl₂ / 1 h / -10 °C

2.1: 95 percent / H₂ / Pd-C / ethyl acetate / 48 h / 20 °C

3.1: 70 percent / LiN(TMS)2 / tetrahydrofuran / 2 h / -78 °C

4.1: m-CPBA; NaHCO₃ / H₂O; CH₂Cl₂ / 1 h / 20 °C

4.2: 87 percent / benzene / 0.5 h / Heating

With hydrogen; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate;