1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:593288-88-1
Molecular Formula:C₂₈H₃₆N₂O₆S₂
Molecular Weight:560.736
Hs Code.:

Synonyms:1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

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Chemical Property of 1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

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Technology Process of 1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

There total 10 articles about 1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1212-08-4
S-Phenyl benzenethiosulfonate

: 221526-49-4
1,1-dimethylethyl (4R)-4-[(3RS)-1-benzenesulfonyl-2-oxopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

: 593288-88-1
1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield:

: 221526-48-3
4-(1-benzenesulfonyl-2-oxo-piperidin-3-ylidenemethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 593288-88-1
1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / Pd-C / ethyl acetate / 48 h / 20 °C

2: 70 percent / LiN(TMS)2 / tetrahydrofuran / 2 h / -78 °C

With hydrogen; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 221526-47-2
1,1-dimethylethyl (4S)-4-[(RS)-[(3RS)-3-benzenesulfonyl-2-oxopiperidin-3-yl]hydroxymethyl]-2,2-dimethyloxazolidine-3-carboxylate

: 593288-88-1
1,1-dimethylethyl (4R)-4-[(1RS)-1-benzenesulfonyl-2-oxo-3-phenylthiopiperidin-3-yl]methyl-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: MsCl; Et₃N / CH₂Cl₂ / 3.5 h / 0 - 20 °C

1.2: 71 percent / DBU / CH₂Cl₂ / 1 h / -10 °C

2.1: 95 percent / H₂ / Pd-C / ethyl acetate / 48 h / 20 °C

3.1: 70 percent / LiN(TMS)2 / tetrahydrofuran / 2 h / -78 °C

With hydrogen; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;