4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester

Base Information

• Chemical Name: 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester
• CAS No.: 121811-03-8
• Molecular Formula: C₂₀H₂₃N₃O₅S₂
• Molecular Weight: 449.552
• Mol file: 121811-03-8.mol

Synonyms:4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester

Chemical Property of 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester

There total 4 articles about 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(2-(diethylamino)ethoxy)benzoyl chloride (121811-19-6) + 6-hydroxy-2-benzothiazolesulfonamide (29927-14-8) → 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester (121811-03-8)

Guidance literature:

With pyridine; dmap; at 25 ℃; for 1.5h;

DOI:10.1021/jm00131a011

Reference yield:

6-ethoxybenzothiazole-2-sulfonamide (452-35-7) → 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester (121811-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / AlCl₃ / 1,2-dichloro-ethane / 20 h / 25 °C

2: 64 percent / pyridine, 4-(dimethylamino)pyridine / 1.5 h / 25 °C

With pyridine; dmap; aluminium trichloride; In 1,2-dichloro-ethane;

DOI:10.1021/jm00131a011

Reference yield:

6-ethoxy-2-mercaptobenzothiazole (120-53-6) → 4-(2-Diethylamino-ethoxy)-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester (121811-03-8)

Guidance literature:

Multi-step reaction with 4 steps

1: conc. NH₄OH, NaOCl, 2.01 M aq. NaOH / 0.25 h / 0 - 5 °C

2: 80 percent / KMnO₄, 1 N H₂SO₄ / acetone; H₂O / 1 h / pH=8.0 - 8.1

3: 66 percent / AlCl₃ / 1,2-dichloro-ethane / 20 h / 25 °C

4: 64 percent / pyridine, 4-(dimethylamino)pyridine / 1.5 h / 25 °C

With pyridine; dmap; ammonium hydroxide; sodium hydroxide; sodium hypochlorite; potassium permanganate; sulfuric acid; aluminium trichloride; In water; 1,2-dichloro-ethane; acetone;

DOI:10.1021/jm00131a011

upstream raw materials:

4-(2-(diethylamino)ethoxy)benzoyl chloride

6-hydroxy-2-benzothiazolesulfonamide

6-ethoxybenzothiazole-2-sulfonamide

6-ethoxy-2-mercaptobenzothiazole