1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol

Base Information

• Chemical Name: 1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol
• CAS No.: 1259071-46-9
• Molecular Formula: C₁₄H₂₀O₂
• Molecular Weight: 220.312
• Mol file: 1259071-46-9.mol

Synonyms:1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol

Chemical Property of 1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol

There total 1 articles about 1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-methyl-1,2-epoxypropane (558-30-5) + 1-bromo-4-methyloxy-2-(prop-1-en-2-yl)benzene (171512-97-3) → 1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol (1259071-46-9)

Guidance literature:

1-bromo-4-methyloxy-2-(prop-1-en-2-yl)benzene; With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 1h;

2-methyl-1,2-epoxypropane; In diethyl ether; hexane; at 0 ℃; for 3h;

DOI:10.3987/COM-10-12021

Reference yield:

1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol (1259071-46-9) → 7-methoxy-1,3,3-trimethyl-1-(phenylsulfanylmethyl)-1H-3,4-dihydro-2-benzopyran (1259072-00-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen iodide / acetonitrile / 1 h / 0 - 20 °C

2.1: iodine; sodium hydrogencarbonate / acetonitrile / 0.5 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

3.2: 4 h / 80 °C

With hydrogen iodide; iodine; sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; acetonitrile; mineral oil;

DOI:10.3987/COM-10-12021

upstream raw materials:

2-methyl-1,2-epoxypropane

1-bromo-4-methyloxy-2-(prop-1-en-2-yl)benzene

Downstream raw materials:

7-methoxy-1,3,3-trimethyl-1-(phenylsulfanylmethyl)-1H-3,4-dihydro-2-benzopyran