171512-97-3

Upstream product

• 6342-63-8 1-(2-bromo-5-methoxyphenyl)ethanone 
• 20667-19-0 methyltriphenylphosphonium iodide 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 
• 71095-23-3 1-(2′-bromo-5′-methoxyphenyl)ethan-1-ol 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 853271-15-5 2-(2-bromo-5-methoxyphenyl) propan-2-ol 

Downstream Products

• 1020726-54-8 1-[4-methoxy-2-(1-methylethenyl)phenyl]cyclohexanol 
• 1203447-27-1 4-methoxy-2-(prop-1-en-2-yl)benzoic acid 
• 1242592-28-4 4-methoxy-2-(1-methylethen-1-yl)-N-phenylbenzamide 
• 1242592-29-5 N-(1,1-dimethylethyl)-4-methoxy-2-(1-methylethen-1-yl)benzamide 
• 1259071-46-9 1-[4-methoxy-2-(1-methylethenyl)phenyl]-2-methylpropan-2-ol 
• 1259072-00-8 7-methoxy-1,3,3-trimethyl-1-(phenylsulfanylmethyl)-1H-3,4-dihydro-2-benzopyran 
• 1259071-48-1 1-[4-methoxy-2-(1-methylethenyl)phenyl]propan-2-ol 
• 1379534-73-2 C₁₇H₂₈O₂Si₂ 
• 1596361-45-3 C₁₆H₂₂O₂Si 
• 1610833-56-1 3-(2-bromo-5-methoxyphenyl)-3-methylcyclobutan-1-one 

Relevant academic research and scientific papers

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Reported here is the development of a class of chiral spirosilabiindane scaffolds by Rh-catalyzed asymmetric double hydrosilation, for the first time. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for the preparation of various chiral ligands and catalysts, was readily prepared on greater than 10 gram scale using this protocol. The potential of this new spirosilabiindane scaffold in asymmetric catalysis was preliminarily demonstrated by development of the corresponding monodentate phosphoramidite ligands (SPSiPhos), which were used in both a Rh-catalyzed hydrogenation and a Pd-catalyzed intramolecular carboamination.

Preparation method of silicon spiro compound (by machine translation)

The invention discloses a preparation method of a silicon spiro compound. The invention provides a preparation method of a silicon spiro compound as shown in a formula II, which comprises the following steps: in a solvent, a compound represented by the formula III is subjected to cyclization reaction under the presence of a monovalent rhodium catalyst and a phosphine ligand to obtain the silicon spiro compound as shown in the formula II. The preparation method of the silicon spiro compound can be simple. , The establishment of the silicon spiro compound is realized conveniently and efficiently. (by machine translation)

Pd-Catalyzed Enantioselective Ring Opening/Cross-Coupling and Cyclopropanation of Cyclobutanones

A palladium-catalyzed enantioselective sequential ring-opening/cross-coupling of cyclobutanones is disclosed that provides chiral indanones bearing C3-quaternary stereocenters. The reaction process involves palladium-catalyzed nucleophilic addition of cyc

Preparation of isoindolinones via a palladium-catalyzed diamination

A Pd(II)-catalyzed cyclization using oxidative olefin diamination was developed for the preparation of isoindolinones from ortho-olefinic N-methoxybenzamides. Using the optimized reaction conditions, the desired products were obtained in up to 90% yield using NFSI as the oxidant. This reaction provides an efficient and direct access to isoindolinones with amine functionality, an important drug skeleton.

Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines

A copper-catalyzed amino lactonization of unsaturated carboxylic acids has been achieved as well as the analogous intermolecular three-component amino oxygenation of olefins. The transformation features mild conditions and a remarkably broad substrate sco

Enantioselective Bromo-oxycyclization of Silanol

Relying on the nucleophilicity of silanol for building up silicon-incorporated scaffold with an enantiopure tetrasubstituted carbon center remains elusive. In this report, asymmetric bromo-oxycyclization of olefinic silanol by using chiral anionic phase-transfer catalyst is described. This protocol provided a facile entry to a wide arrangement of enantiopure benzoxasilole in moderate to excellent enantioselectivities depending on the unique reactivity of bromine/N-benzyl-DABCO complex.

Palladium-Catalyzed Aerobic Aminooxygenation of Alkenes for Preparation of Isoindolinones

A palladium-catalyzed intramolecular isoindolinone-forming aminooxygenation of alkenes with 1 atm of oxygen as oxidant is reported. A variety of functionalized alkenes and carboxylic acids can be used, and high yields were observed. Preliminary mechanistic studies revealed that the aminooxygenation products were formed through the oxidation of a C-PdII species using a strong oxidant, peroxide, which is generated in situ from a Pd(OAc)2/bpy/O2/HOAc catalytic system.

Cleavage of C-C and C-Si σ-bonds and their intramolecular exchange

C-C and C-Si σ-bonds are cleaved to undergo bond exchange when substrates equipped with cyclobutanone and silacyclobutane moieties are treated with a palladium(0) catalyst. The skeletal exchange results in construction of silabicyclo[5.2.1]decanes in a diastereoselective manner.

Intramolecular σ-bond metathesis between carbon-carbon and silicon-silicon bonds

An intramolecular σ-bond metathesis between carbon-carbon and silicon-silicon bonds took place on treatment of a disilane tethered to a cyclobutanone with a palladium(0) catalyst, furnishing a silaindane skeleton as well as an acylsilane functionality at

Pd-Catalyzed intramolecular oxyalkynylation of alkenes with hypervalent iodine

(Figure presented) The first example of intramolecular oxyalkynylation of nonactivated alkenes using oxidative Pd chemistry is reported. Both phenol and aromatic or aliphatic acid derivatives could be used under operator-friendly conditions (room temperature, technical solvents, under air). The discovery of the superiority of benzlodoxolone-derlved hypervalent iodine reagent 3d as an alkyne transfer reagent further expands the rapidly increasing utility of hypervalent iodine reagents in catalysis and is expected to have important implications for other similar processes.