1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine

Base Information

• Chemical Name: 1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine
• CAS No.: 1100094-77-6
• Molecular Formula: C₁₉H₃₀BNO₄
• Molecular Weight: 347.262

Synonyms:1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine

Chemical Property of 1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine

Chemical Property:

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Technology Process of 1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine

There total 1 articles about 1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-methoxyphenylboronic acid pinacol ester (269410-22-2) + N-(2-chloroethyl)-pyrrolidine (5050-41-9) → 1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine (1100094-77-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 3h;

Reference yield:

3-amino-6-bromo-pyrazine-2-carboxylic acid (486424-37-7) + 1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine (1100094-77-6) → 3-amino-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazine-2-carboxylic acid (1100094-74-3)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; at 160 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

1-{2-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}pyrrolidine (1100094-77-6) + 2-amino-3-bromo-5-iodopyridine (697300-73-5) → 3-bromo-5-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]pyridin-2-amine (1449301-22-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃;

upstream raw materials:

4-hydroxy-3-methoxyphenylboronic acid pinacol ester

N-(2-chloroethyl)-pyrrolidine

Downstream raw materials:

3-amino-6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazine-2-carboxylic acid

3-bromo-5-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]pyridin-2-amine

N-[4-(2-amino-5-{3-methoxy-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}pyridin-3-yl)phenyl]-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide

3-(4-aminophenyl)-5-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]pyridin-2-amine

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