Piperazine, 1-(2H-1-benzopyran-3-ylcarbonyl)-4-phenyl-

Base Information

• Chemical Name: Piperazine, 1-(2H-1-benzopyran-3-ylcarbonyl)-4-phenyl-
• CAS No.: 83823-09-0
• Molecular Formula: C₂₀H₂₀N₂O₂
• Molecular Weight: 320.391
• NSC Number: 147846
• UNII: EJ7VY5VDR1
• DSSTox Substance ID: DTXSID70232715
• Wikidata: Q83113817
• Mol file: 83823-09-0.mol

Synonyms:Piperazine, 1-(2H-1-benzopyran-3-ylcarbonyl)-4-phenyl-;EJ7VY5VDR1;83823-09-0;NSC-147846;1-(2H-1-Benzopyran-3-ylcarbonyl)-4-phenyl-piperazine;NSC 147846;BRN 4546813;NSC147846;1-(2H-1-Benzopyran-3-ylcarbonyl)-4-phenylpiperazine;UNII-EJ7VY5VDR1;DTXSID70232715;AKOS002053295;CCG-191462;1-(2H-chromene-3-carbonyl)-4-phenylpiperazine;(2H-Chromen-3-yl)(4-phenylpiperazin-1-yl)methanone;2H-1-BENZOPYRAN-3-YL(4-PHENYL-1-PIPERAZINYL)METHANONE;METHANONE, 2H-1-BENZOPYRAN-3-YL(4-PHENYL-1-PIPERAZINYL)-

Chemical Property of Piperazine, 1-(2H-1-benzopyran-3-ylcarbonyl)-4-phenyl-

Chemical Property:

• Vapor Pressure: 1.88E-12mmHg at 25°C
• Boiling Point: 557.2°Cat760mmHg
• Flash Point: 290.8°C
• Density: 1.238g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 320.152477885
• Heavy Atom Count: 24
• Complexity: 476

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1C2=CC=CC=C2)C(=O)C3=CC4=CC=CC=C4OC3

Technology Process of Piperazine, 1-(2H-1-benzopyran-3-ylcarbonyl)-4-phenyl-

There total 5 articles about Piperazine, 1-(2H-1-benzopyran-3-ylcarbonyl)-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

salicylaldehyde (90-02-8) → (2H-Chromen-3-yl)-(4-phenyl-piperazin-1-yl)-methanone (83823-09-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 16 percent / 20percent aq.NaOH

2: 94.7 percent / 10percent NaOH / 5 h / Heating

3: SOCl₂ / benzene / 3 h / Heating

4: Et₃N / benzene

With sodium hydroxide; thionyl chloride; triethylamine; In benzene;

Reference yield:

2H-chromene-3-carbonitrile (57543-66-5) → (2H-Chromen-3-yl)-(4-phenyl-piperazin-1-yl)-methanone (83823-09-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / 10percent NaOH / Heating

2: SOCl₂ / benzene / 3 h / Heating

3: Et₃N / benzene

With sodium hydroxide; thionyl chloride; triethylamine; In benzene;

Reference yield:

Chromene-3-carboxamide (10185-00-9) → (2H-Chromen-3-yl)-(4-phenyl-piperazin-1-yl)-methanone (83823-09-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 94.7 percent / 10percent NaOH / 5 h / Heating

2: SOCl₂ / benzene / 3 h / Heating

3: Et₃N / benzene

With sodium hydroxide; thionyl chloride; triethylamine; In benzene;

upstream raw materials:

4-phenyl-1-piperazine

chlorure d'acide chromene carboxylique-3

2H-chromene-3-carbonitrile

Chromene-3-carboxamide

Downstream raw materials:

1-Chroman-3-ylmethyl-4-phenyl-piperazine

1-(2H-Chromen-3-ylmethyl)-4-phenyl-piperazine