Technology Process of 4-(3-bromobenzoyl)nicotinic acid
There total 5 articles about 4-(3-bromobenzoyl)nicotinic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-((3-bromophenyl)(hydroxy)methyl)-N,N-diisopropyl nicotinamide;
With
formic acid;
for 24h;
Reflux;
With
ammonia;
In
methanol;
at 20 ℃;
for 3h;
With
hydrogenchloride;
In
methanol; water;
pH=1;
- Guidance literature:
-
C13H11BrN2O2;
With
methanol; ammonia;
at 20 ℃;
for 72h;
With
hydrogenchloride;
In
methanol; water;
pH=1;
DOI:10.1016/j.ejmech.2010.07.016
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C / Inert atmosphere
2.1: lithium diisopropyl amide / n-heptane; diethyl ether; tetrahydrofuran / -78 - -50 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: ethanol; sodium tetrahydroborate / 3 h / 20 °C
4.1: formic acid / 24 h / Reflux
4.2: 3 h / 20 °C
4.3: pH 1
With
sodium tetrahydroborate; formic acid; ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; n-heptane; acetonitrile;
