(R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

Base Information

Chemical Name:(R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal
CAS No.:1043450-58-3
Molecular Formula:C₂₁H₂₀FNO₅
Molecular Weight:385.392
Hs Code.:

Synonyms:(R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

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Chemical Property of (R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

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Technology Process of (R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

There total 7 articles about (R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1043450-57-2
(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)pent-4-enoyl)oxazolidin-2-one

: 1043450-58-3
(R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

Guidance literature:: (S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)pent-4-enoyl)oxazolidin-2-one; With ozone; In dichloromethane; at -70 ℃; for 0.5h;

With triphenylphosphine; In dichloromethane; at -70 - 20 ℃; for 3h;

Reference yield:

: 1043450-39-0
ethyl 2-(4-fluoro-3-methylphenoxy)acetate

: 1043450-58-3
(R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / 1,4-dioxane / 0.5 h / 20 - 25 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

3.2: 2 h / -70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

4.2: 1 h / -70 °C

5.1: ozone / dichloromethane / 0.5 h / -70 °C

5.2: 3 h / -70 - 20 °C

With potassium hydroxide; n-butyllithium; oxalyl dichloride; water; ozone; lithium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

Reference yield:

: 452-70-0
4-fluoro-3-methylphenol

: 1043450-58-3
(R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / sodium iodide / acetone / 3 h / 25 - 63 °C

2.1: potassium hydroxide; water / 1,4-dioxane / 0.5 h / 20 - 25 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 25 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

4.2: 2 h / -70 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

5.2: 1 h / -70 °C

6.1: ozone / dichloromethane / 0.5 h / -70 °C

6.2: 3 h / -70 - 20 °C

With potassium hydroxide; n-butyllithium; oxalyl dichloride; water; potassium carbonate; ozone; lithium hexamethyldisilazane; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; acetone;