N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester

Base Information

Chemical Name:N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester
CAS No.:126541-95-5
Molecular Formula:C₁₃H₁₃F₃N₂O₇
Molecular Weight:366.251
Hs Code.:

Synonyms:N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester

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Chemical Property of N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester

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Technology Process of N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester

There total 5 articles about N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 126541-94-4
N-[3-Hydroxy-4-(trifluormethyl)benzoyl]-L-threonin-methylester

: 128995-23-3
N-<3-Hydroxy-6-nitro-4-(trifluormethyl)benzoyl>-L-threonin-methylester

: 126541-95-5
N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester

Guidance literature:: With nitric acid; In acetic acid; at 50 ℃;

Reference yield:

: 455-24-3
4-trifluoromethylbenzoic acid

: 126541-95-5
N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester

Guidance literature:: Multi-step reaction with 5 steps

1: 25 percent / HNO₃ (d=1.5) / 1 h / Heating

2: 88 percent / H₂ / Pd/A-Kohle / methanol

3: 70 percent / NaNO₂, aq. H₂SO₄ / acetic acid / -5 deg C, 15 min, then room temp., 2h, then reflux, 3 min

4: 301 mg / N-Methylmorpholin, 1-Hydroxybenzotriazol, DCC / dimethylformamide; CH₂Cl₂ / 0 deg C, 2h, then room temp., 16h

5: 42 percent / HNO₃ (d=1.42) / acetic acid / 50 °C

With 4-methyl-morpholine; sulfuric acid; hydrogen; nitric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium nitrite; A-Kohle; palladium; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 116965-16-3
3-nitro-4-(trifluoromethyl)benzoic acid

: 126541-95-5
N-[3-Hydroxy-2-nitro-4-(trifluormethyl)benzoyl]-L-threonin-methylester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / H₂ / Pd/A-Kohle / methanol

2: 70 percent / NaNO₂, aq. H₂SO₄ / acetic acid / -5 deg C, 15 min, then room temp., 2h, then reflux, 3 min

3: 301 mg / N-Methylmorpholin, 1-Hydroxybenzotriazol, DCC / dimethylformamide; CH₂Cl₂ / 0 deg C, 2h, then room temp., 16h

4: 42 percent / HNO₃ (d=1.42) / acetic acid / 50 °C

With 4-methyl-morpholine; sulfuric acid; hydrogen; nitric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium nitrite; A-Kohle; palladium; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;