2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

Base Information

Chemical Name:2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole
CAS No.:204516-43-8
Molecular Formula:C₄₂H₃₈N₈O
Molecular Weight:670.817
Hs Code.:

Synonyms:2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

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Chemical Property of 2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

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Technology Process of 2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

There total 7 articles about 2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 204516-42-7
2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxyaldehyde

: 204516-43-8
2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

Guidance literature:: With hydrogenchloride; sodium borohydrid; In ethanol-tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 151521-90-3
3-amino-4-ethyl-5-diethoxymethyl-1H-pyrazole

: 204516-43-8
2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 4 h / Heating

2: H₂NOH / methanol / 16 h / Ambient temperature

3: pyridine / N,N-dimethyl-acetamide / 2 h / Ambient temperature

4: pyridine / methanol / 2 h / Heating

5: 92 percent / NaBH₄ / ethanol / 1 h

6: 1.) KOt-Bu / 1.) DMF, 20 min, 2.) DMF, RT, overnight

With pyridine; sodium tetrahydroborate; potassium tert-butylate; hydroxylamine; In methanol; ethanol; N,N-dimethyl acetamide; toluene;
DOI:10.1248/cpb.46.287

Reference yield:

: 151406-81-4
2,7-diethyl-1H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxyaldehyde

: 204516-43-8
2,7-diethyl-6-hydroxymethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaBH₄ / ethanol / 1 h

2: 1.) KOt-Bu / 1.) DMF, 20 min, 2.) DMF, RT, overnight

With sodium tetrahydroborate; potassium tert-butylate; In ethanol;
DOI:10.1248/cpb.46.287