1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

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Chemical Name:1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide
CAS No.:455312-13-7
Molecular Formula:C₃₃H₃₄N₆O₉S
Molecular Weight:690.734
Hs Code.:

Synonyms:1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

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Chemical Property of 1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

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Technology Process of 1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

There total 9 articles about 1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 455312-08-0
(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

: 455312-13-7
1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

Guidance literature:: With caesium carbonate; In methanol;
DOI:10.1021/ja027121e

Reference yield:

: 5427-82-7
1H-pyrrole-2-carbonyl chloride

: 455312-13-7
1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N

2: 94 percent / aq. Cs₂CO₃ / methanol

With caesium carbonate; triethylamine; In methanol;
DOI:10.1021/ja027121e

Reference yield:

: 143724-89-4
Trimethyl-((R)-3-oxiranyl-prop-1-ynyl)-silane

: 455312-13-7
1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaN₃; NH₄Cl

1.2: 67 percent / nBuLi; PMe₃

2.1: NaNTMS₂

3.1: n-Bu₄NF

4.1: n-Bu₃SnCl; LiNTMS₂

4.2: -42 °C

5.1: 34 percent / n-Bu₃SnCl / 1,2-dimethoxy-ethane / Heating

6.1: Et₃N

7.1: 94 percent / aq. Cs₂CO₃ / methanol

With sodium azide; tributyltin chloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; ammonium chloride; caesium carbonate; triethylamine; lithium hexamethyldisilazane; In methanol; 1,2-dimethoxyethane;
DOI:10.1021/ja027121e