5427-82-7Relevant articles and documents
[NO]- and [NN]-coordination mode rhodium complexes based on a flexible ligand: Synthesis, reactivity and catalytic activity
Yao, Zi-Jian,Li, Kuan,Zhang, Jian-Yong,Deng, Wei
, p. 8753 - 8759 (2016)
A flexible [NON]-type ligand was prepared via a stepwise method. Air- and moisture-stable LL- (N,O-coordination mode) (1) and LX-type (N,N-coordination mode) (2) rhodium(i) complexes were synthesized based on this flexible ligand under different reaction conditions. The two rhodium complexes were isolated in good yields and characterized by elemental analysis and IR and NMR spectrometry. The molecular structures of complexes 1 and 2 were confirmed by single-crystal X-ray analysis. The cationic rhodium complex was shown to be a good catalyst for the hydrogenation of acetophenone derivatives without pre-dried solvents and reagents. Good efficiency was achieved for a series of substrates with either electron-donating or electron-withdrawing groups.
Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis
Aiello, Anna,D'Esposito, Monica,Fattorusso, Ernesto,Menna, Marialuisa,Müller, Werner E.G.,Perovi?-Ottstadt, Sanja,Tsuruta, Hideyuki,Gulder, Tobias A.M.,Bringmann, Gerhard
, p. 7266 - 7270 (2005)
The isolation and characterization of the known pyrrole alkaloid agelongine (6) and of the new natural product daminin (7), the bromine-free analogue of 6, from a specimen of the marine sponge Axinella damicornis is described. Compound 7 showed significant neuroprotective properties. Moreover, for the supply of sufficient material for future medicinal investigations, a short total synthesis of 7 was developed.
Alternating current electrolysis for organic electrosynthesis: Trifluoromethylation of (hetero)arenes
Rodrigo, Sachini,Um, Chanchamnan,Mixdorf, Jason C.,Gunasekera, Disni,Nguyen, Hien M.,Luo, Long
supporting information, p. 6719 - 6723 (2020/07/30)
Paired electrolysis has a limited reaction scope for organic synthesis because it is often not compatible with reactions involving short-lived intermediates. We addressed this limitation using alternating current electrolysis (ACE). Using trifluoromethyla
Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin
Lounsbury, Nicole,Eidem, Tess,Colquhoun, Jennifer,Mateo, George,Abou-Gharbia, Magid,Dunman, Paul M.,Childers, Wayne E.
supporting information, p. 1127 - 1131 (2018/02/21)
We recently discovered RnpA as a promising new drug discovery target for methicillin-resistant S. aureus (MRSA). RnpA is an essential protein that is thought to perform two required cellular processes. As part of the RNA degrasome Rnpa mediates RNA degradation. In combination with rnpB it forms RNase P haloenzymes which are required for tRNA maturation. A high throughput screen identified RNPA2000 as an inhibitor of both RnpA-associated activities that displayed antibacterial activity against clinically relevant strains of S. aureus, including MRSA. Structure-activity studies aimed at improving potency and replacing the potentially metabotoxic furan moiety led to the identification of a number of more potent analogs. Many of these new analogs possessed overt cellular toxicity that precluded their use as antibiotics but two derivatives, including compound 5o, displayed an impressive synergy with mupirocin, an antibiotic used for decolonizing MSRA whose effectiveness has recently been jeopardized by bacterial resistance. Based on our results, compounds like 5o may ultimately find use in resensitizing mupirocin-resistant bacteria to mupirocin.
