<(1R)-1-amino>-3-methylbutyl>phosphonic acid

Base Information

Chemical Name:<(1R)-1-amino>-3-methylbutyl>phosphonic acid
CAS No.:128948-77-6
Molecular Formula:C₁₃H₂₀NO₅P
Molecular Weight:301.279
Hs Code.:

<(1R)-1-<N-<(phenylmethoxy)carbonyl>amino>-3-methylbutyl>phosphonic acid

Synonyms:<(1R)-1-amino>-3-methylbutyl>phosphonic acid

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Chemical Property of <(1R)-1-amino>-3-methylbutyl>phosphonic acid

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Technology Process of <(1R)-1-amino>-3-methylbutyl>phosphonic acid

There total 5 articles about <(1R)-1-amino>-3-methylbutyl>phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88081-77-0
L-Leucine phosphonate

: 501-53-1,94274-21-2
benzyl chloroformate

: 128948-77-6
<(1R)-1-amino>-3-methylbutyl>phosphonic acid

Guidance literature:: With sodium hydroxide; sodium hydrogencarbonate; sodium carbonate; In water; Yield given; Ambient temperature;
DOI:10.1021/jo00313a012

Reference yield:

: 107-86-8
3,3-dimethyl acrylaldehyde

: 128948-77-6
<(1R)-1-amino>-3-methylbutyl>phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / 3A molecular sieves / CH₂Cl₂ / 3 h / 23 °C

2: 64 percent / (R,R)-1,2-diaminocyclohexane thiourea reagent / diethyl ether / 72 h / 4 °C

3: 93 percent / H₂ / Pd/C / methanol / 72 h / 23 °C

4: triethylamine / dioxane; H₂O / 16 h / 23 °C

With 3 A molecular sieve; hydrogen; triethylamine; (R,R)-(+)-trans-4,5-tetramethyleneimidazolidine-2-thione; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja0494398

Reference yield:

: 111865-48-6
benzyl-(3-methyl-but-2-enylidene)amine

: 128948-77-6
<(1R)-1-amino>-3-methylbutyl>phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / (R,R)-1,2-diaminocyclohexane thiourea reagent / diethyl ether / 72 h / 4 °C

2: 93 percent / H₂ / Pd/C / methanol / 72 h / 23 °C

3: triethylamine / dioxane; H₂O / 16 h / 23 °C

With hydrogen; triethylamine; (R,R)-(+)-trans-4,5-tetramethyleneimidazolidine-2-thione; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; water;
DOI:10.1021/ja0494398