cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>

Base Information

Chemical Name:cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>
CAS No.:89278-33-1
Molecular Formula:C₃₁H₄₅ClN₄O₆
Molecular Weight:605.174
Hs Code.:

Synonyms:cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>

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Chemical Property of cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>

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Technology Process of cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>

There total 16 articles about cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 89321-01-7
Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

: 89278-33-1
cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>

Guidance literature:: With hydrogen; 4-pyrrolidin-1-ylpyridine; palladium on activated charcoal; In 1,4-dioxane; ethanol; at 95 ℃; for 5h;
DOI:10.1055/s-1986-31636

Reference yield:

: 108071-96-1
Methyl 2(S)-benzyloxycarbonylamino-10-hydroxy-8(S),9(S)-O-isopropylidenedecanoate

: 89278-33-1
cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>

Guidance literature:: Multi-step reaction with 6 steps

1: 1-chlor-1-dimethylamino-2-methyl-1-propen, pyridine / CH₂Cl₂ / 1.) -20 deg C, 30 min 2.) 40 deg C, 30 min

2: NaOH pH<11 / H₂O; dioxane / 5 h / Ambient temperature

3: DCCD / ethyl acetate / -20 deg C to RT

4: NaOH / H₂O; dioxane / 5 h / Ambient temperature

5: DCCD / ethyl acetate / -20 deg C to RT

6: 94 percent / H₂ / Pd / dioxane / 5 h / 95 °C

With pyridine; sodium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydrogen; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

: 108071-98-3
Methyl of N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

: 89278-33-1
cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl>

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH / H₂O; dioxane / 5 h / Ambient temperature

2: DCCD / ethyl acetate / -20 deg C to RT

3: 94 percent / H₂ / Pd / dioxane / 5 h / 95 °C

With sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; water; ethyl acetate;