(2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

Base Information

Chemical Name:(2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one
CAS No.:219715-79-4
Molecular Formula:C₂₀H₂₁NO₅S
Molecular Weight:387.456
Hs Code.:

Synonyms:(2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

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Chemical Property of (2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

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Technology Process of (2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

There total 1 articles about (2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 219715-78-3
(R)-N-[1'-(2-Furyl)-2'-benzyloxyethyl]toluene-p-sulfonamide

: 219715-79-4
(2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(98)02129-7

Reference yield: 97.0%

: 122-51-0
orthoformic acid triethyl ester

: 219715-79-4
(2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

: 219715-80-7
(2R,6R)-2-Benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

Guidance literature:: With 4 A molecular sieve; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(98)02129-7

Reference yield:

: 219715-79-4
(2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

: 219715-88-5
(2R,3S,6S)-1-tosyl-3-hydroxy-2-hydroxymethyl-6-dodecylpiperidine

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / tetrahydrofuran / 0 °C

2: 88 percent / NaBH₄ / methanol / 0 °C

3: 85 percent / NaH / tetrahydrofuran / Ambient temperature

4: 1.0 eq. TiCl₄ / CH₂Cl₂ / -78 °C

5: 1.) BH₃*SMe₂; 2.) NaOH, H₂O₂ / 1.) THF

6: 87 percent / NaH / tetrahydrofuran / 0 °C

7: 68 percent / Li₂CuCl₄ / tetrahydrofuran / 0 °C

8: 84 percent / H₂ / 10 percent Pd/C / ethanol

With sodium hydroxide; sodium tetrahydroborate; dilithium tetrachlorocuprate; dimethylsulfide borane complex; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; dihydrogen peroxide; titanium tetrachloride; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(98)02129-7