(2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

Base Information

Chemical Name:(2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine
CAS No.:219715-82-9
Molecular Formula:C₂₉H₃₅NO₅S
Molecular Weight:509.667
Hs Code.:

Synonyms:(2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

Suppliers and Price of (2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

There total 4 articles about (2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-39-0
benzyl bromide

: 219715-81-8
(2R,3S,6R)-2-Benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidin-3-ol

: 219715-82-9
(2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4039(98)02129-7

Reference yield:

: 219715-78-3
(R)-N-[1'-(2-Furyl)-2'-benzyloxyethyl]toluene-p-sulfonamide

: 219715-82-9
(2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / m-CPBA / CH₂Cl₂ / Ambient temperature

2: 97 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / tetrahydrofuran / 0 °C

3: 88 percent / NaBH₄ / methanol / 0 °C

4: 85 percent / NaH / tetrahydrofuran / Ambient temperature

With sodium tetrahydroborate; 4 A molecular sieve; boron trifluoride diethyl etherate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)02129-7

Reference yield:

: 219715-79-4
(2R,6R)-2-Benzyloxymethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one

: 219715-82-9
(2R,3S,6R)-3-Benzyloxy-2-benzyloxymethyl-6-ethoxy-1-(toluene-4-sulfonyl)-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / tetrahydrofuran / 0 °C

2: 88 percent / NaBH₄ / methanol / 0 °C

3: 85 percent / NaH / tetrahydrofuran / Ambient temperature

With sodium tetrahydroborate; 4 A molecular sieve; boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(98)02129-7