Technology Process of ethyl 9Z-13-demethylretinoate
There total 3 articles about ethyl 9Z-13-demethylretinoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl (2E)-4-(diethoxyphosphoryl)crotonate;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 0.5h;
(2Z,4E)-3-methyl-5-[2,6,6-trimethylcyclohex-1-enyl]penta-2,4-dienal;
In
tetrahydrofuran; hexane;
for 2h;
DOI:10.1016/j.bmc.2004.04.047
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 87 percent / Ph3As / Pd2(dba)3*CHCl3 / dimethylformamide / 2 h / 20 °C
2.1: 75 percent / MnO2 / diethyl ether / 4 h
3.1: n-BuLi; DMPU / tetrahydrofuran; hexane / 0.5 h / 0 °C
3.2: 71 percent / tetrahydrofuran; hexane / 2 h
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; manganese(IV) oxide; n-butyllithium; triphenyl-arsane;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
1.1: Stille coupling;
DOI:10.1016/j.bmc.2004.04.047
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 75 percent / MnO2 / diethyl ether / 4 h
2.1: n-BuLi; DMPU / tetrahydrofuran; hexane / 0.5 h / 0 °C
2.2: 71 percent / tetrahydrofuran; hexane / 2 h
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; manganese(IV) oxide; n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.1016/j.bmc.2004.04.047
