2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol

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Chemical Name:2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol
CAS No.:1394289-90-7
Molecular Formula:C₂₆H₂₁BrN₆O₂
Molecular Weight:529.396
Hs Code.:

Synonyms:2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol

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Chemical Property of 2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol

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Technology Process of 2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol

There total 4 articles about 2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1394289-62-3
C₂₅H₂₀BrN₃O₃

: 50-01-1
guanidine hydrochloride

: 1394289-90-7
2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 100 ℃;
DOI:10.1016/j.bmc.2012.07.009

Reference yield:

: 1394289-44-1
C₁₈H₁₆BrN₃O₃

: 1394289-90-7
2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 4 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 100 °C

With sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; 1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmc.2012.07.009

Reference yield:

: 67091-10-5
1-(2-hydroxy-4-prop-2-ynyloxy-phenyl)-ethanone

: 1394289-90-7
2-(2-amino-6-phenylpyrimidin-4-yl)-5-{(1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy}phenol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 4 h / 20 °C

2: potassium hydroxide / ethanol / 4 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 - 100 °C

With copper(ll) sulfate pentahydrate; sodium hydride; sodium L-ascorbate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmc.2012.07.009