Technology Process of 1-[3-Isopropoxy-5-(7-pyrimidin-2-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea
There total 8 articles about 1-[3-Isopropoxy-5-(7-pyrimidin-2-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
In
1,4-dioxane; water;
at 20 - 90 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: titanium(III) chloride / tetrahydrofuran / 48 h / 20 °C
3.1: tetrahydrofuran / 1 h / 60 °C
3.2: 20 - 60 °C
4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 10 h / 100 °C / Inert atmosphere
5.1: potassium phosphate / 1,4-dioxane; water / 20 - 90 °C / Inert atmosphere
With
potassium phosphate; titanium(III) chloride; potassium acetate; potassium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
5.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate; tricyclohexylphosphine / palladium diacetate / water; diethylene glycol / 15 h / 100 °C / Inert atmosphere
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / Inert atmosphere
3: N-iodo-succinimide / acetonitrile / 20 °C
4: potassium phosphate / 1,4-dioxane; water / 20 - 90 °C / Inert atmosphere
With
potassium phosphate; N-iodo-succinimide; potassium carbonate; tricyclohexylphosphine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate;
In
1,4-dioxane; water; acetonitrile; diethylene glycol;
4: Suzuki Coupling;
