Imidazo[1,2-a]pyridine-7-boronic acid pinacol ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-7-boronic acid pinacol ester
• CAS No.: 908268-52-0
• Molecular Formula: C13H17BN2O2
• Molecular Weight: 244.101
• Hs Code.: 2934999090
• Mol file: 908268-52-0.mol

Synonyms:7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)H-imidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine-7-boronic acid pinacol ester; 7-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-imidazo[1,2-a]pyridine

Chemical Property of Imidazo[1,2-a]pyridine-7-boronic acid pinacol ester

Chemical Property:

• PKA: 6.50±0.50(Predicted)
• PSA: 35.76000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 1.63350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Imidazo[1,2-a]pyridine-7-boronicacidpinacolester 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-7-boronic acid pinacol ester

There total 5 articles about Imidazo[1,2-a]pyridine-7-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-chloroimidazo-[1,2-a]pyridine (4532-25-6) + bis(pinacol)diborane (73183-34-3) → 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)imidazo[1,2-a]pyridine (908268-52-0)

Guidance literature:

7-chloroimidazo-[1,2-a]pyridine; bis(pinacol)diborane; With potassium acetate; tricyclohexylphosphine; In diethylene glycol dimethyl ether; water; for 0.0833333h;

palladium diacetate; In diethylene glycol dimethyl ether; water; at 100 ℃; for 17h;

With potassium carbonate; In diethylene glycol dimethyl ether; water; for 18h;

Reference yield: 70.0%

2-chloroethanal (107-20-0) + 4-(4,4,5 ,5-tetramethyl-1,3 ,2-dioxaborolan-2-yl)pyridin-2-amine (1195995-72-2) → 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)imidazo[1,2-a]pyridine (908268-52-0)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 80 ℃; for 12h;

Reference yield:

7-bromoimidazo[1,2-a]pyridine (808744-34-5) + bis(pinacol)diborane (73183-34-3) → 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)imidazo[1,2-a]pyridine (908268-52-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 90 ℃; for 18h; Sealed tube; Inert atmosphere; Microwave irradiation;

upstream raw materials:

7-chloroimidazo-[1,2-a]pyridine

bis(pinacol)diborane

7-bromoimidazo[1,2-a]pyridine

2-amino-4-bromopyridine

Downstream raw materials:

1-[3-Isopropoxy-5-(7-pyrimidin-2-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea