1380112-29-7

Usage

Chemical structure

2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate features an aminomethyl group, two benzyloxy functional groups, and a pyridin-4-one ring.

Functional groups

The compound has both aminomethyl (-NH2CH2-) and benzyloxy (-OCH2C6H5) functional groups attached to the pyridin-4-one ring.

Salt form

It exists as a methanesulfonate salt, which enhances its solubility and stability.

Common use

The compound is frequently used as an intermediate in the synthesis of pharmaceuticals and other organic compounds.

Versatility

Its unique structure and reactivity make it a valuable building block for creating a variety of complex molecules.

Application in industry

2-(aMinoMethyl)-1,5-bis(benzyloxy)pyridin-4(1H)-one Methanesulfonate is a useful tool for synthetic chemists and researchers in the pharmaceutical industry.

Upstream product

• 15771-06-9 5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one 
• 1380109-79-4 C₂₈H₂₂N₂O₅ 
• 1380109-78-3 C₂₁H₂₁NO₆S 
• 1380109-77-2 5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one 
• 1380109-74-9 C₂₀H₁₉NO₄ 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 
• 75-75-2 methanesulfonic acid 
• 1380109-80-7 2-(aminomethyl)-1,5-bis(benzyloxy)-1,4-dihydropyridin-4-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 1380111-65-8 C₂₆H₂₂FN₃O₄ 
• 1380111-59-0 C₂₉H₂₆N₂O₆ 
• 1380111-46-5 C₂₇H₂₄N₂O₇S 
• 1380110-39-3 tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate 
• 1380111-05-6 C₄₃H₅₁ClN₈O₁₁S 
• 1380111-53-4 C₂₄H₂₄N₂O₆ 
• 1380111-79-4 C₂₆H₂₂FN₃O₄ 
• 1380112-07-1 C₂₇H₂₄N₂O₇S 
• 1380111-50-1 C₂₃H₂₂N₂O₆ 
• 1380111-56-7 C₂₉H₂₆N₂O₆ 
• 1380111-00-1 1-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-({(2R,3S)-2-[({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamoyl}amino)methyl]-4-oxo-1-sulfoazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)cyclohexane carboxylic acid 
• 1445727-65-0 C₄₃H₅₂N₈O₁₁S 
• 1445727-83-2 C₄₁H₄₂N₈O₉S 
• 1445727-84-3 C₂₂H₂₂N₈O₁₀S₂ 

Relevant academic research and scientific papers

Pyridone-conjugated monobactam antibiotics with gram-negative activity

Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Rat pharmacokinetic studies with compound 17 demonstrate low clearance and low plasma protein binding. In addition, evidence is provided for a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug uptake in P. aeruginosa strain PAO1.

MONOBACTAMS

The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.