tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

Base Information

Chemical Name:tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate
CAS No.:1380110-39-3
Molecular Formula:C₃₉H₄₅N₅O₉
Molecular Weight:727.814
Hs Code.:

Synonyms:tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

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Chemical Property of tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

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Technology Process of tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

There total 9 articles about tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1380110-38-2
tert-butyl [(2R,3S)-2-(aminomethyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl]carbamate

: 1380112-29-7
CH₄O₃S*C₂₀H₂₀N₂O₃

: 530-62-1
1,1'-carbonyldiimidazole

: 1380110-39-3
tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

Guidance literature:: CH₄O₃S*C₂₀H₂₀N₂O₃; With tripotassium phosphate "n" hydrate; In dichloromethane; water; at 22 ℃; for 1h;

1,1'-carbonyldiimidazole; In dichloromethane; at 22 ℃; for 4h; Inert atmosphere;

tert-butyl [(2R,3S)-2-(aminomethyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl]carbamate; In dichloromethane; N,N-dimethyl-formamide; at 22 - 40 ℃; for 15h;

Reference yield:

: 1380109-77-2
5-(benzyloxy)-1-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one

: 1380110-39-3
tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / dimethyl sulfoxide / 1 h / 20 - 25 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: potassium iodide / N,N-dimethyl-formamide / 20 - 25 °C

4.1: hydrazine hydrate / ethanol / 1 h / Reflux

5.1: water; ethyl acetate / 20 - 50 °C

6.1: tripotassium phosphate "n" hydrate / dichloromethane; water / 1 h / 22 °C

6.2: 4 h / 22 °C / Inert atmosphere

6.3: 15 h / 22 - 40 °C

With tripotassium phosphate "n" hydrate; potassium carbonate; hydrazine hydrate; triethylamine; potassium iodide; In ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1380112-32-2
C₁₈H₁₄O₈*C₁₈H₂₇N₃O₅

: 1380110-39-3
tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / water; ethyl acetate / 0.5 h / 20 - 25 °C / Diatomaceous earth

2.1: tripotassium phosphate "n" hydrate / dichloromethane; water / 1 h / 22 °C

2.2: 4 h / 22 °C / Inert atmosphere

2.3: 15 h / 22 - 40 °C

With potassium phosphate; tripotassium phosphate "n" hydrate; In dichloromethane; water; ethyl acetate;