(S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate

Base Information

• Chemical Name: (S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate
• CAS No.: 1363553-28-9
• Molecular Formula: C₁₉H₂₁NO₄
• Molecular Weight: 327.38
• Mol file: 1363553-28-9.mol

Synonyms:(S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate

Chemical Property of (S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate

There total 2 articles about (S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,2-bis(bromomethyl)-4,5-dimethoxybenzene (26726-81-8) + L-2-phenylglycine methyl ester hydrochloride (15028-39-4,13226-98-7) → (S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate (1363553-28-9)

Guidance literature:

With potassium hydrogencarbonate; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

1,2-dimethoxybenzene (91-16-7) → (S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate (1363553-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / 12 h / 20 °C / Inert atmosphere

2: potassium hydrogencarbonate / acetonitrile / 20 °C / Inert atmosphere

With hydrogen bromide; potassium hydrogencarbonate; acetic acid; In acetonitrile;

DOI:10.1016/j.tetlet.2012.01.013

Reference yield: 30.0%

(S)-methyl 2-(5,6-dimethoxyisoindolin-2-yl)-2-phenylacetate (1363553-28-9) + chloroformic acid ethyl ester (541-41-3) → (S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)(ethoxycarbonyl)amino)-2-phenylacetate (1363553-34-7) + Methyl (R)-2-chloro-2-phenylethanoate (59204-21-6,7476-66-6,60208-35-7,116836-54-5) + (S)-2-chloro-2-phenylacetic acid methyl ester

Guidance literature:

In 1,2-dichloro-ethane; optical yield given as %ee; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2012.01.013

upstream raw materials:

1,2-dimethoxybenzene

1,2-bis(bromomethyl)-4,5-dimethoxybenzene

L-2-phenylglycine methyl ester hydrochloride

Downstream raw materials:

(S)-methyl 2-((2-(chloromethyl)-4,5-dimethoxybenzyl)(ethoxycarbonyl)amino)-2-phenylacetate

Methyl (R)-2-chloro-2-phenylethanoate