ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

Base Information

Chemical Name:ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate
CAS No.:937055-12-4
Molecular Formula:C₃₂H₃₇ClN₂O₇
Molecular Weight:597.108
Hs Code.:

Synonyms:ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

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Chemical Property of ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

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Technology Process of ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

There total 12 articles about ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937054-53-0
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

: 937057-85-7
ethyl 2-[(3R)-piperidin-3-yloxy]acetate

: 937055-12-4
ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 937057-83-5,881656-67-3
2-({(3R)-1-[(benzyloxy)carbonyl]piperidin-3-yl}oxy)acetic acid

: 937055-12-4
ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / benzene / 4 h

2: hydrogen / palladium 10% on activated carbon / ethanol

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

With 4-methyl-morpholine; sulfuric acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide; benzene;

Reference yield:

: 937057-84-6
benzyl (3R)-3-(2-ethoxy-2-oxoethoxy)-1-piperidinecarboxylate

: 937055-12-4
ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;