2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid

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Chemical Name:2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid
CAS No.:937055-13-5
Molecular Formula:C₃₀H₃₃ClN₂O₇
Molecular Weight:569.054
Hs Code.:

Synonyms:2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid

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Chemical Property of 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid

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Technology Process of 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid

There total 13 articles about 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937055-12-4
ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate

: 937055-13-5
2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid

Guidance literature:: ethyl 2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetate; With ethanol; water; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 72h;

With hydrogenchloride; water; In tetrahydrofuran; pH=3;

Reference yield:

: 937057-84-6
benzyl (3R)-3-(2-ethoxy-2-oxoethoxy)-1-piperidinecarboxylate

: 937055-13-5
2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

3.1: ethanol; water; potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3.2: pH 3

With 4-methyl-morpholine; ethanol; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 937059-64-8
benzyl (3R)-3-[2-(t-butoxy)-2-oxoethoxy]-1-piperidinecarboxylate

: 937055-13-5
2-[((3R)-1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}piperidin-3-yl)oxy]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.1: sulfuric acid / benzene / 4 h

3.1: hydrogen / palladium 10% on activated carbon / ethanol

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: ethanol; water; potassium carbonate / tetrahydrofuran / 72 h / 20 °C

5.2: pH 3

With 4-methyl-morpholine; ethanol; sulfuric acid; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;