D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester

Base Information

Chemical Name:D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester
CAS No.:174743-71-6
Molecular Formula:C₃₂H₄₂N₂O₉
Molecular Weight:598.693
Hs Code.:

Synonyms:D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester

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Chemical Property of D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester

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Technology Process of D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester

There total 9 articles about D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 174743-70-5
benzyloxycarbonyl D-phenylalanyl L-α-hydroxyisovaleryl-O-acetyl L-tyrosyl D-lactic acid t-butyl ester

: 174743-71-6
D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate; at 0 ℃; for 13h;
DOI:10.1016/0040-4020(95)00963-9

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 174743-71-6
D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 20 h

2: 100 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

3: 76 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 17 h / 0 °C

4: 93 percent / H₂, AcOH / 10percent Pd/C / ethyl acetate / 13 h / 0 °C

With dmap; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/0040-4020(95)00963-9

Reference yield:

: 68166-83-6
D-lactic acid t-butyl ester

: 174743-71-6
D-phenylalanyl L-α-hydroxyisovaleryl O-acetyl L-tyrosyl D-lactic acid t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 18 h / 0 °C

2: 76 percent / dimethylaminopyridine, DCC / CH₂Cl₂ / 17 h / 0 °C

3: 93 percent / H₂, AcOH / 10percent Pd/C / ethyl acetate / 13 h / 0 °C

With dmap; hydrogen; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/0040-4020(95)00963-9