Amosulalol

Base Information

• Chemical Name: Amosulalol
• CAS No.: 85320-68-9
• Molecular Formula: C18H24N2O5S
• Molecular Weight: 380.465
• UNII: C69JI1BAU8
• DSSTox Substance ID: DTXSID90868893
• Nikkaji Number: J239.723D
• Wikipedia: Amosulalol
• Wikidata: Q4747983
• NCI Thesaurus Code: C72916
• ChEMBL ID: CHEMBL152231
• Mol file: 85320-68-9.mol

Synonyms:5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide;amosulalol;YM 09538;YM-09538

Chemical Property of Amosulalol

Chemical Property:

• Boiling Point: 608.7°Cat760mmHg
• Flash Point: 321.9°C
• PSA: 119.26000
• Density: 1.268g/cm³
• LogP: 3.52500
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 380.14059304
• Heavy Atom Count: 26
• Complexity: 510

Purity/Quality:

98%Min ^*data from raw suppliers

AMOSULALOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)C(CNCCOC2=CC=CC=C2OC)O)S(=O)(=O)N
• Description: Amosulalol is a potent antihypertensive with combined alpha and beta blocking properties. Indicated for the treatment of essential hypertension, it appears to possess a minimum of side-effects. Its beta-blocking property reduces the tachycardia associated with alpha-blockers, while its alpha-blocking activity reduces the peripheral vasoconstriction associated with beta-blockade.
• Therapeutic Function: Alpha-adrenergic blocker, Beta-adrenergic blocker, Antihypertensive

Technology Process of Amosulalol

There total 4 articles about Amosulalol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-{1-hydroxy-2-[N-benzyl-2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide (70958-78-0) → amosulalol (85320-68-9,94666-15-6,94666-17-8)

Guidance literature:

With hydrogenchloride; palladium charcoal; In methanol; ethanol; hydrogen;

Reference yield:

5-acetyl-2-methylbenzenesulfonamide (70958-70-2) → amosulalol (85320-68-9,94666-15-6,94666-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid

2: (i), (ii) NaBH₄, (iii) H₂, Pd-C

With bromine; acetic acid;

Reference yield:

5-((2-Bromo-1-oxo)ethyl)-2-methylbenzenesulfonamide (70958-71-3) + N-[2-(2'-(methoxy)-phenoxy)-ethyl]-benzylamine (3246-03-5) → amosulalol (85320-68-9,94666-15-6,94666-17-8)

Guidance literature:

Multistep reaction; (i), (ii) NaBH₄, (iii) H₂, Pd-C;

upstream raw materials:

5-((2-Bromo-1-oxo)ethyl)-2-methylbenzenesulfonamide

N-[2-(2'-(methoxy)-phenoxy)-ethyl]-benzylamine

5-{1-hydroxy-2-[N-benzyl-2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide

5-acetyl-2-methylbenzenesulfonamide

Refernces

• 1、 -. "ANTIHYPERTENSIVE THERAPY". . . Retrieved 2009/09/08.
• 2、 -. "PHENYLETHANOLAMINE DERIVATIVES". . . Retrieved 2008/06/13.