Amosulalol

Base Information

Chemical Name:Amosulalol
CAS No.:85320-68-9
Molecular Formula:C18H24N2O5S
Molecular Weight:380.465
Hs Code.:
UNII:C69JI1BAU8
DSSTox Substance ID:DTXSID90868893
Nikkaji Number:J239.723D
Wikipedia:Amosulalol
Wikidata:Q4747983
NCI Thesaurus Code:C72916
ChEMBL ID:CHEMBL152231
Mol file:85320-68-9.mol

Synonyms:5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide;amosulalol;YM 09538;YM-09538

Suppliers and Price of Amosulalol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
AMOSULALOL 95.00%
1G
$ 2355.15

American Custom Chemicals Corporation
AMOSULALOL 95.00%
5MG
$ 501.09

Total 9 raw suppliers

Chemical Property of Amosulalol

Chemical Property:

Boiling Point:608.7°Cat760mmHg
Flash Point:321.9°C
PSA：119.26000
Density:1.268g/cm³
LogP:3.52500
XLogP3:1.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:380.14059304
Heavy Atom Count:26
Complexity:510

Purity/Quality:

99% up by HPLC ^*data from raw suppliers

AMOSULALOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)C(CNCCOC2=CC=CC=C2OC)O)S(=O)(=O)N
Description Amosulalol is a potent antihypertensive with combined alpha and beta blocking properties. Indicated for the treatment of essential hypertension, it appears to possess a minimum of side-effects. Its beta-blocking property reduces the tachycardia associated with alpha-blockers, while its alpha-blocking activity reduces the peripheral vasoconstriction associated with beta-blockade.
Therapeutic Function Alpha-adrenergic blocker, Beta-adrenergic blocker, Antihypertensive

Technology Process of Amosulalol

There total 4 articles about Amosulalol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70958-78-0
5-{1-hydroxy-2-[N-benzyl-2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide

: 85320-68-9,94666-15-6,94666-17-8
amosulalol

Guidance literature:: With hydrogenchloride; palladium charcoal; In methanol; ethanol; hydrogen;

Reference yield:

: 70958-70-2
5-acetyl-2-methylbenzenesulfonamide

: 85320-68-9,94666-15-6,94666-17-8
amosulalol

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid

2: (i), (ii) NaBH₄, (iii) H₂, Pd-C

With bromine; acetic acid;