(R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

Base Information

Chemical Name:(R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate
CAS No.:1443368-71-5
Molecular Formula:C₃₀H₂₇NO₅
Molecular Weight:481.548
Hs Code.:

Synonyms:(R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

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Chemical Property of (R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

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Technology Process of (R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

There total 3 articles about (R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6121-42-2
1-Phenyl-cyclopropanecarboxylic acid methyl ester

: 1443368-70-4
(R)-1-phenylethyl (2-(4-bromophenyl)furan-3-yl)carbamate

: 1443368-71-5
(R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 12h;

Reference yield:

: 122943-01-5
2-(4-bromophenyl)furan-3-carboxylic acid

: 1443368-71-5
(R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 3.83 h / 20 - 90 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 12 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1443368-71-5
(R)-methyl 1-(4'-(3-(((1-phenylethoxy)carbonyl)amino)furan-2-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 °C

1.2: copper dichloride dehydrate / 48 h / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 3.83 h / 20 - 90 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 12 h / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; potassium carbonate; triethylamine; sodium nitrite; In 1,2-dimethoxyethane; water; toluene;