1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

Base Information

Chemical Name:1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid
CAS No.:1010413-70-3
Molecular Formula:C₂₆H₂₃F₂NO₂
Molecular Weight:419.471
Hs Code.:

Synonyms:1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

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Chemical Property of 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

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Technology Process of 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

There total 2 articles about 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 412006-68-9
ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

: 141776-91-2
1-bromomethyl-3,5-difluoro-benzene

: 1010413-70-3
1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

Guidance literature:: ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate; 1-bromomethyl-3,5-difluoro-benzene; With potassium tert-butylate; In N,N-dimethyl acetamide; at 20 ℃; for 3h;

With potassium hydroxide; water; In N,N-dimethyl acetamide; at 60 ℃;

With hydrogenchloride; water; In N,N-dimethyl acetamide; at 20 - 30 ℃;

Reference yield:

: 1010413-73-6
ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

: 1010413-70-3
1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

Guidance literature:: With potassium hydroxide; In N,N-dimethyl acetamide; water; at 60 ℃; for 1h; Large scale reaction;
DOI:10.1021/op800211c

Reference yield: 84.0%

: 1010413-70-3
1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

: 1-[(3,5-bis{[2-(methyloxy)ethyl]oxy}phenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

Guidance literature:: 2-methoxy-ethanol; With potassium tert-butylate; In toluene; at 80 ℃; for 0.5h;

1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In toluene; at 20 - 80 ℃;

With hydrogenchloride; water; In toluene; at 60 ℃; Product distribution / selectivity;