ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate
CAS No.:1010413-73-6
Molecular Formula:C₂₈H₂₇F₂NO₂
Molecular Weight:447.525
Hs Code.:

Synonyms:ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

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Technology Process of ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

There total 1 articles about ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 412006-68-9
ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

: 141776-91-2
1-bromomethyl-3,5-difluoro-benzene

: 1010413-73-6
ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

Reference yield: 78.0%

: 1010413-73-6
ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 1010413-36-1
ethyl 1-[(3,5-bis{[2-(methyloxy)ethyl]oxy}phenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Guidance literature:: ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate; 2-methoxy-ethanol; With potassium tert-butylate; In 1,2-dimethoxyethane; at 80 ℃; for 16h;

With hydrogenchloride; water; In 1,2-dimethoxyethane; pH=1; Product distribution / selectivity;

Reference yield:

: 1010413-73-6
ethyl 1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

: 1010413-70-3
1-[(3,5-difluorophenyl)methyl]-3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylic acid

Guidance literature:: With potassium hydroxide; In N,N-dimethyl acetamide; water; at 60 ℃; for 1h; Large scale reaction;
DOI:10.1021/op800211c