ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate
CAS No.:412006-68-9
Molecular Formula:C₂₁H₂₃NO₂
Molecular Weight:321.419
Hs Code.:

Synonyms:ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Suppliers and Price of ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Chemical Property:

Boiling Point:490.4±40.0 °C(Predicted)
Density:1.115±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

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Technology Process of ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

There total 4 articles about ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 91348-45-7
3-bromo-1H-indole-2-carboxylic acid ethyl ester

: 123324-71-0
p-tert-butylphenylboronic acid

: 412006-68-9
ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Guidance literature:: With potassium phosphate; [(t-Bu)3PH]BF₄; palladium diacetate; In water; butan-1-ol; at 20 ℃; for 6h; Inert atmosphere; Glovebox;
DOI:10.1002/ejoc.201402915

Reference yield: 89.0%

: 123324-71-0
p-tert-butylphenylboronic acid

: 117637-79-3
ethyl 3-iodo-1H-indole-2-carboxylate

: 412006-68-9
ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Guidance literature:: With potassium carbonate; In isopropyl alcohol; at 85 - 90 ℃; for 24h;
DOI:10.1021/cs400468h

Reference yield: 82.0%

: 1246775-33-6
ethyl 3-(4-bromophenyl)-1H-indole-2-carboxylate

: 123324-71-0
p-tert-butylphenylboronic acid

: 412006-68-9
ethyl 3-[4-(1,1-dimethylethyl)phenyl]-1H-indole-2-carboxylate

Guidance literature:: ethyl 3-(4-bromophenyl)-1H-indole-2-carboxylate; p-tert-butylphenylboronic acid; With palladium diacetate; potassium hydrogencarbonate; tris-(o-tolyl)phosphine; In water; isopropyl alcohol; at 60 ℃; for 2h; Inert atmosphere;

With sodium hydrogen sulfate; In toluene; at 60 ℃; for 1h; Reagent/catalyst; Temperature; Time; Solvent;
DOI:10.1021/op800064y