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Sumatriptan succinate

Base Information Edit
  • Chemical Name:Sumatriptan succinate
  • CAS No.:103628-48-4
  • Molecular Formula:C18H27N3O6S
  • Molecular Weight:413.495
  • Hs Code.:29350090
  • European Community (EC) Number:600-463-4
  • NSC Number:760362
  • UNII:J8BDZ68989
  • DSSTox Substance ID:DTXSID60145966
  • Wikidata:Q10374626
  • NCI Thesaurus Code:C29470
  • RXCUI:67158
  • ChEMBL ID:CHEMBL1201150
  • Mol file:103628-48-4.mol
Sumatriptan succinate

Synonyms:3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide;GR 43175;GR-43175;GR43175;Imigran;Succinate, Sumatriptan;Sumatriptan;Sumatriptan Succinate

Suppliers and Price of Sumatriptan succinate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Sumatriptan succinate
  • 10mg
  • $ 339.00
  • Usbiological
  • Sumatriptan Succinate
  • 50mg
  • $ 403.00
  • TRC
  • Sumatriptan succinate
  • 50mg
  • $ 110.00
  • Tocris
  • Sumatriptan succinate ≥99%(HPLC)
  • 10
  • $ 102.00
  • Tocris
  • Sumatriptan succinate ≥99%(HPLC)
  • 50
  • $ 413.00
  • TCI Chemical
  • Sumatriptan Succinate >98.0%(HPLC)(T)
  • 1g
  • $ 525.00
  • TCI Chemical
  • Sumatriptan Succinate >98.0%(HPLC)(T)
  • 100mg
  • $ 108.00
  • Sigma-Aldrich
  • Sumatriptan succinate ≥98% (HPLC), solid
  • 10mg
  • $ 98.10
  • Sigma-Aldrich
  • Sumatriptan succinate European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Sumatriptan for system suitability European Pharmacopoeia (EP) Reference Standard
  • y0000027
  • $ 190.00
Total 164 raw suppliers
Chemical Property of Sumatriptan succinate Edit
Chemical Property:
  • Appearance/Colour:white powder 
  • Vapor Pressure:1.24E-17mmHg at 25°C 
  • Melting Point:165-166°C 
  • Boiling Point:497.7 °C at 760 mmHg 
  • Flash Point:254.8 °C 
  • PSA:148.18000 
  • Density:1.243 g/cm3 
  • LogP:2.72870 
  • Storage Temp.:Store at +4°C 
  • Solubility.:H2O: >20mg/mL 
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:9
  • Exact Mass:413.16205676
  • Heavy Atom Count:28
  • Complexity:498
Purity/Quality:

99.9% *data from raw suppliers

Sumatriptan succinate *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38-41 
  • Safety Statements: 26-36-39 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C.C(CC(=O)O)C(=O)O
  • Recent ClinicalTrials:Sofusa System With Sumatriptan (KC5010) Phase 1 Dose Escalation Safety and PK Study (KCC-SMT-002)
  • Recent EU Clinical Trials:Sumatriptan non-responders: evaluation of a possible biomarker
  • Description Sumatriptan succinate is a synthetic drug belonging to a class of medications known as 5-hydroxytryptamine agonists (also called "triptans"), which is commonly used to treat cluster and migraine headaches with or without aura (warning signs occurring prior to the onset of a migraine). It is effective to relieve or eliminate the intensity of migraine and cluster headaches and accompanying symptoms including sensitivity to light or sound, nausea, and vomiting. However, it cannot help prevent future migraines/headaches or decrease the frequency of getting migraine and it is not recommended for other types of headache or for headache prevention. It is believed that the pain of migraine headaches is induced by dilated blood vessels inside the head. Sumatriptan succinate relieves migraine headaches by affecting the serotonin in the brain, which results in constriction of blood vessels. Subcutaneous injection of this drug is more effective than other formulations. Sumatriptan succinate is a highly selective 5HT1-like receptor agonist introduced as a new treatment for migraine. It is indicated for the acute relief of migraine and cluster headache. Oral administration is reported to be free of substantial side effects. The compound appears to be a significant advance over the use of ergotamine and other agents in the treatment of migraine.
  • Uses A serotonin 5HT1-receptor agonist A selective 5-HT1 receptor agonist Sumatriptan (succinate) is a serotonin 5-hydroxytryptamine 1 (5-HT1) receptor agonist with selective affinity for 5-HT1B and 5-HT1D receptors with IC50 values of 9.3 and 7.3 nM, respectively. It also has affinity for the 5-HT1F receptor (IC50 = 17.8 nM). Sumatriptan (succinate) has been shown to induce vasoconstriction of human middle meningeal arteries (EC50 = 89.9 nM) and reduce vascular inflammation associated with migraines. Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).
Technology Process of Sumatriptan succinate

There total 3 articles about Sumatriptan succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With succinic acid; In acetone; at 25 - 35 ℃; for 1 - 2h; Heating / reflux;
Guidance literature:
succinic acid; sumatripan; In water; acetonitrile; for 0.25 - 0.5h; Heating / reflux;
In cyclohexane; at 25 - 35 ℃; for 1 - 2h;
Guidance literature:
upstream raw materials:

sumatripan

succinic acid

Downstream raw materials:

sumatripan

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