1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate

Base Information

• Chemical Name: 1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate
• CAS No.: 155635-65-7
• Molecular Formula: C₁₇H₁₄F₃N₃O
• Molecular Weight: 333.313
• Mol file: 155635-65-7.mol

Synonyms:1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate

Chemical Property of 1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate

There total 3 articles about 1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine (114085-00-6) + Triethyl orthoacetate (78-39-7) → 1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate (155635-65-7)

Guidance literature:

With acetic acid; In toluene; for 2h; Heating;

DOI:10.1016/0022-1139(93)02936-9

Reference yield:

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (3335-44-2) → 1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate (155635-65-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 86.4 percent / K₂CO₃, NaI / acetone / 6 h / 60 °C

2: 83.6 percent / K₂CO₃ / dimethylformamide / 2 h / 110 - 120 °C

3: 85.6 percent / CH₃COOH / toluene / 2 h / Heating

With potassium carbonate; acetic acid; sodium iodide; In N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1016/0022-1139(93)02936-9

Reference yield:

2-((3-cyano-6-phenyl-4-(trifluoromethyl)pyridin-2-yl)oxy)acetamide (155635-57-7) → 1-ethyl N-1-[3-cyano-6-phenyl-4-(trifluoromethyl)-2-pyridyl]ethanimidate (155635-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 83.6 percent / K₂CO₃ / dimethylformamide / 2 h / 110 - 120 °C

2: 85.6 percent / CH₃COOH / toluene / 2 h / Heating

With potassium carbonate; acetic acid; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/0022-1139(93)02936-9

upstream raw materials:

2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine

Triethyl orthoacetate

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

2-((3-cyano-6-phenyl-4-(trifluoromethyl)pyridin-2-yl)oxy)acetamide

Downstream raw materials:

3-ethyl-2-methyl-7-phenyl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-imine