N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate

Base Information

Chemical Name:N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate
CAS No.:690273-47-3
Molecular Formula:C₂H₂O₄*C₂₄H₂₄F₃N₃OS
Molecular Weight:549.571
Hs Code.:

Synonyms:N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate

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Chemical Property of N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate

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Technology Process of N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate

There total 5 articles about N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 690273-46-2
N-[1-benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide

: 144-62-7,97993-78-7
oxalic acid

: 690273-47-3
N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate

Guidance literature:: In isopropyl alcohol;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 690273-47-3
N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1.17 h / 0 - 40 °C

1.2: 0 °C / pH 10

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: 0.5 h / -30 - 0 °C

3.1: triethylamine / dmap / dichloromethane / 2.25 h / 0 - 20 °C

4.1: isopropyl alcohol

With n-butyllithium; triethylamine; dmap; In tetrahydrofuran; hexane; dichloromethane; acetic acid; isopropyl alcohol;

Reference yield:

: 120115-93-7
1-benzyl-4-(4-methylthiazol-2-yl)-4-anilinopiperidine

: 690273-47-3
N-[1-Benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-2,2,2-trifluoro-N-phenylacetamide oxalate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dmap / dichloromethane / 2.25 h / 0 - 20 °C

2: isopropyl alcohol

With triethylamine; dmap; In dichloromethane; isopropyl alcohol;