tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate

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Chemical Name:tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate
CAS No.:816424-96-1
Molecular Formula:C₃₀H₃₁FN₄O₄S
Molecular Weight:562.665
Hs Code.:

Synonyms:tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate

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Chemical Property of tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate

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Technology Process of tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate

There total 9 articles about tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 639482-11-4
pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

: 122536-76-9,140629-77-2
3(S)-(tert-butoxycarbonylamino)pyrrolidine

: 816424-96-1
tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 816424-96-1
tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / ethanol / 4.5 h / Heating / reflux

2.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 4 h / 20 - 25 °C

2.2: 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18.5 h / 20 °C

3.2: pH 8.5

4.1: trifluoroacetic anhydride / DMF (N,N-dimethyl-formamide) / 1.25 h / 20 °C

5.1: pyridine; copper diacetate / dichloromethane / 18 h / 20 °C

6.1: / toluene / 0.08 h

6.2: 24 h / Heating / reflux

7.1: lithium hydroxide; ethanol; water / tetrahydrofuran / 80 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

8.2: 24 h / 20 °C

9.1: dichloromethane / 18 h / 20 °C

With pyridine; lithium hydroxide; tert.-butylnitrite; ethanol; water; copper diacetate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; copper(ll) bromide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 514182-57-1
3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylic acid ethyl ester

: 816424-96-1
tert-butyl [(3S)-1-({3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: / toluene / 0.08 h

1.2: 24 h / Heating / reflux

2.1: lithium hydroxide; ethanol; water / tetrahydrofuran / 80 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

3.2: 24 h / 20 °C

4.1: dichloromethane / 18 h / 20 °C

With lithium hydroxide; ethanol; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; toluene;