2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate

Base Information

Chemical Name:2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate
CAS No.:866102-79-6
Molecular Formula:C₃₁H₃₇N₃O₆
Molecular Weight:547.651
Hs Code.:

Synonyms:2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate

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Chemical Property of 2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate

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Technology Process of 2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate

There total 7 articles about 2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 866102-78-5
4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoic acid

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 866102-79-6
2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate

Guidance literature:: 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoic acid; With 1,1'-carbonyldiimidazole; In 1,2-dimethoxyethane; for 2h; Heating;

2-(N,N-dimethylamino)ethanol; With sodium hydride; In 1,2-dimethoxyethane; for 8h;
DOI:10.1021/jm0502485

Reference yield:

: 866102-74-1
N-(4-bromophenyl)butane-1,4-diamine

: 866102-79-6
2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / Et₃N / CH₂Cl₂ / 8 h

2.1: 89 percent / 1-methyl-pyrrolidin-2-one / 1.5 h / 200 °C

3.1: 85 percent / aq. HBr / 4 h / Heating

4.1: 68 percent / sodium phosphate buffer / 24 h / 20 °C / pH 12

5.1: N,N'-carbonyldiimidazole / 1,2-dimethoxy-ethane / 2 h / Heating

5.2: 92 percent / NaH / 1,2-dimethoxy-ethane / 8 h

With sodium phosphate buffer; hydrogen bromide; triethylamine; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm0502485

Reference yield:

: 866102-77-4
4-[(4-aminobutyl)amino]benzoic acid

: 866102-79-6
2-(dimethylamino)ethyl 4-[[(benzyloxy)carbonyl](4-{[(benzyloxy)carbonyl]amino}butyl)amino]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / sodium phosphate buffer / 24 h / 20 °C / pH 12

2.1: N,N'-carbonyldiimidazole / 1,2-dimethoxy-ethane / 2 h / Heating

2.2: 92 percent / NaH / 1,2-dimethoxy-ethane / 8 h

With sodium phosphate buffer; 1,1'-carbonyldiimidazole; In 1,2-dimethoxyethane;
DOI:10.1021/jm0502485