5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol

Base Information

• Chemical Name: 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol
• CAS No.: 939052-08-1
• Molecular Formula: C₂₀H₂₂N₂O₄
• Molecular Weight: 354.406
• Mol file: 939052-08-1.mol

Synonyms:5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol

Chemical Property of 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol

Chemical Property:

Purity/Quality:

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Technology Process of 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol

There total 1 articles about 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)benzoic acid (939054-33-8) + ethyl potassium malonate (6148-64-7) → 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol (939052-08-1)

Guidance literature:

5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)benzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 50 ℃; for 17h; Heating / reflux;

With hydrazine; In ethanol; for 5h; Heating / reflux;

Reference yield:

5-hydroxyethyl-4-methylthiazole (137-00-8,8042-97-5) + 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol (939052-08-1) → 5-(2-(5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-yloxy)ethyl)-4-methylthiazole

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 70 ℃; for 15h;

Reference yield:

methanol (67-56-1) + 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-1H-pyrazol-3-ol (939052-08-1) → 5-(5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)phenyl)-3-methoxy-1H-pyrazole

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 70 ℃; for 15h;

upstream raw materials:

5-(benzyloxy)-2-(1-methoxypropan-2-yloxy)benzoic acid

ethyl potassium malonate