ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane

Base Information

• Chemical Name: ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane
• CAS No.: 1360471-30-2
• Molecular Formula: C₂₁H₂₉NOSi
• Molecular Weight: 339.553
• Mol file: 1360471-30-2.mol

Synonyms:ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane

Chemical Property of ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane

There total 3 articles about ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl(iodomethyl)diphenylsilane (1360471-29-9) + (2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) → ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane (1360471-30-2)

Guidance literature:

With triethylamine; In toluene; for 72h; Reflux; Inert atmosphere;

DOI:10.1039/c1cc15872d

Reference yield:

chloro(chloromethyl)diphenylsilane (2632-78-2) → ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane (1360471-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / diethyl ether / Inert atmosphere

1.2: 18 h / 0 - 20 °C / Inert atmosphere

2.1: sodium iodide / acetone / 48 h / Reflux; Inert atmosphere

3.1: triethylamine / toluene / 72 h / Reflux; Inert atmosphere

With magnesium; triethylamine; sodium iodide; In diethyl ether; acetone; toluene;

DOI:10.1039/c1cc15872d

Reference yield:

phenylmagnesium bromide (100-58-3) → ethyl[(S)-2-(methoxymethyl)pyrrolidinomethyl]diphenylsilane (1360471-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diethyl ether / Reflux; Inert atmosphere

2.1: magnesium / diethyl ether / Inert atmosphere

2.2: 18 h / 0 - 20 °C / Inert atmosphere

3.1: sodium iodide / acetone / 48 h / Reflux; Inert atmosphere

4.1: triethylamine / toluene / 72 h / Reflux; Inert atmosphere

With magnesium; triethylamine; sodium iodide; In diethyl ether; acetone; toluene;

DOI:10.1039/c1cc15872d

upstream raw materials:

ethyl(iodomethyl)diphenylsilane

(2S)-2-(methoxymethyl)-1-pyrrolidine

chloro(chloromethyl)diphenylsilane

phenylmagnesium bromide